CDK12/13-IN-3 [CAS 3029608-57-6]
CDK12/13-IN-3 [CAS 3029608-57-6]
SKU:QM-0011179-01
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Product Details
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Description
CDK12/13-IN-3 (Compound 12b) is the orally active inhibitor for CDK that inhibits CDK12 and CDK13 with IC50 of 107.4 nM and 79.4 nM. CDK12/13-IN-3 inhibits the phosphorylation of Ser2 on the CTD of RNA polymerase II, induces DNA damage, and downregulates the gene expression of DNA damage response (DDR) . CDK12/13-IN-3 exhibits antiproliferative activity against multiple cancer cells with IC50 of nanomolar levels. CDK12/13-IN-3 exhibits antitumor effect in mouse models, exhibits good pharmacokinetic properties with an oral bioavailability of 53.6%[1].
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CAS Number
[3029608-57-6]
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Molecular Formula
C19H22ClN7O2
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Molecular Weight
415.88
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Smiles
COC1=NC(N[C@@H]2CCN(C3=NC=NC4=C3CCN(C(C=C)=O)C4)C2)=NC=C1Cl
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Target
CDK
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Isoform
CDK12; CDK13
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Shipping Conditions
Room temperature
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CDK12/13-IN-3 [CAS 3029608-57-6]
CDK12/13-IN-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.