CDK12-IN-2 [CAS 2244987-03-7]
CDK12-IN-2 [CAS 2244987-03-7]
SKU:QM-0137613-01
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Product Details
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Description
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12[1].
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CAS Number
[2244987-03-7]
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Molecular Formula
C32H32N6O2
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Molecular Weight
532.64
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Smiles
O=C(NCC1=CC=CC=C1)N([C@H]2CC[C@@H](CC2)NC3=CC=C(C=N3)C#N)C4=CC=C(C5=CN(C(C=C5)=O)C)C=C4
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Target
CDK
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Isoform
CDK12; CDK2; CDK7; CDK9
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Purity
99.36
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H320
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Precautions
H315, H319, H320
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CDK12-IN-2 [CAS 2244987-03-7]
CDK12-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.