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CDK12-IN-4 [CAS 2651196-69-7]
CDK12-IN-4 [CAS 2651196-69-7]
SKU:QM-0063679
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Product Details
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Description
CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM) . CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].
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CAS Number
[2651196-69-7]
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Molecular Formula
C20H20F2N8O
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Molecular Weight
426.42
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Smiles
FC1=C(F)C2=C(N=C(CNC3=NC(N4CCOCC4)=NC5=C(C6CC6)C=NN35)N2)C=C1
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Target
CDK
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Isoform
CDK12; CDK2; CDK9
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK12-IN-4 [CAS 2651196-69-7]
CDK12-IN-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.