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CDK12-IN-5 [CAS 2651200-35-8]
CDK12-IN-5 [CAS 2651200-35-8]
SKU:QM-0146641-01
£306.37 GBP
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Product Details
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Description
CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM) . CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1) [1].
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CAS Number
[2651200-35-8]
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Molecular Formula
C18H15F5N8O
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Molecular Weight
454.36
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Smiles
FC(C1=C2N(N=C1)C(NCC3=NC4=CC=C(F)C(F)=C4N3)=NC(N5CCOCC5)=N2)(F)F
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Target
CDK
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Isoform
CDK12; CDK2; CDK9
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Purity
98.03
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Solubility
DMSO : 125 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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CDK12-IN-5 [CAS 2651200-35-8]
CDK12-IN-5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.