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CDK12-IN-8 [CAS 2928619-86-5]
CDK12-IN-8 [CAS 2928619-86-5]
SKU:QM-0010079
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Product Details
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Description
CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1].
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CAS Number
[2928619-86-5]
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Molecular Formula
C21H20F3N7O2
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Molecular Weight
459.42
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Smiles
N#CC1=CC2=NN=C(N2C=C1)[C@@H](CCC3)C[C@@H]3NC4=NC=C(C(F)(F)F)C(OC5COC5)=N4
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Target
CDK
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Isoform
CDK12
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Shipping Conditions
Room temperature
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CDK12-IN-8 [CAS 2928619-86-5]
CDK12-IN-8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.