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CDK2 degrader 7 [CAS 3030279-55-8]
CDK2 degrader 7 [CAS 3030279-55-8]
SKU:QM-0013463-01
£458.24 GBP
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Product Details
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Description
CDK2 degrader 7 is an orally active CDK2 degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells) . CDK2 degrader 7 induces G1 phase arrest in MKN1 cells. CDK2 degrader 7 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. CDK2 degrader 7 can be used for the study of CCNE1-amplified cancers[1].
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CAS Number
[3030279-55-8]
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Molecular Formula
C39H46F6N8O5S
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Molecular Weight
852.89
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Smiles
O=S(C1=CC=C(NC2=NC=C(C(F)(F)F)C(N3C[C@@](C)(O)CCC3)=N2)C(F)=C1)(N[C@H]4[C@@H](F)CN(CC5CCN(C6=CC=C(C(CC7)C(NC7=O)=O)C=C6F)CC5)CC4)=O
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Target
CDK
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Isoform
CDK1; CDK2
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Shipping Conditions
Room temperature
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CDK2 degrader 7 [CAS 3030279-55-8]
CDK2 degrader 7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.