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CDK2/FLT4/PDGFRA-IN-1
CDK2/FLT4/PDGFRA-IN-1
SKU:QM-0011235
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Product Details
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Description
CDK2/FLT4/PDGFRA-IN-1 (Compound 4a) is a potent inhibitor of CDK2/cyclin A, FLT4 (VEGFR3) and PDGFRA, with IC50s of 1.672, 0.554, and 0.629 μM, respectively. CDK2/FLT4/PDGFRA-IN-1 exhibits potent antiproliferative effects against cancer cells (lung EBC-1, pancreatic ductal adenocarcinoma AsPC-1, colorectal HT-29 cells) . CDK2/FLT4/PDGFRA-IN-1 can also induce apoptosis in cancer cells[1].
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Molecular Formula
C26H20N4O3
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Molecular Weight
436.46
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Smiles
O=C1C(NC2=CC=C(OCC3=CN(CC4=CC=CC=C4)N=N3)C=C2)=CC(C5=C1C=CC=C5)=O
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Target
Apoptosis; CDK; PDGFR; VEGFR
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Shipping Conditions
Room temperature
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CDK2/FLT4/PDGFRA-IN-1
CDK2/FLT4/PDGFRA-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.