CDK2-IN-42
CDK2-IN-42
SKU:QM-0011258
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Product Details
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Description
CDK2-IN-42 (Compound H63) is a CDK12 inhibitor with an IC50 value of 10 nM. CDK2-IN-42 has anti-ESCC (Esophageal Squamous Cell Carcinoma) cell activity. It can block transcriptional elongation, downregulate the core genes in the G1 phase to induce cell cycle arrest, and alter the CDK12-ATM/ATR-CHEK1/CHEK2 signaling axis, resulting in DNA damage. CDK2-IN-42 can effectively inhibit tumor growth in a xenograft mouse model of human ESCC KYSE150. CDK2-IN-42 holds great promise for research in the field of cancer[1].
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Molecular Formula
C19H15N7O4S
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Molecular Weight
437.43
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Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=CC(NC3=NC=CC(C4=CN=C(NC)S4)=N3)=C2
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Target
CDK
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Isoform
CDK12
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Shipping Conditions
Room temperature
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CDK2-IN-42
CDK2-IN-42 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.