CDK4/6-IN-26
CDK4/6-IN-26
SKU:QM-0015790
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Product Details
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Description
CDK4/6-IN-26 is a carbamate derivative that targets CDK4/CDK6. CDK4/6-IN-26 reduces CDK4/CDK6 levels, resulting in cell cycle arrest in the G0/G1 phase and in the S phase. CDK4/6-IN-26 exhibits high potency against SW480 cells (IC50 = 6.3 μM) . CDK4/6-IN-26 affects ROS levels by increasing the expression of SOD2/MnSOD. CDK4/6-IN-26 establishes several interactions with the amino acids of the CDK6 active site. CDK4/6-IN-26 can be used for the research of colorectal cancer[1].
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Molecular Formula
C28H41NO6
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Molecular Weight
487.63
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Smiles
CC(C1=C(OC(C)=O)C(OC(C)=O)=C2[C@@]3(NC(OCC(C)C)=O)CCCC(C)(C)[C@]3([H])CCC2=C1)C
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Target
CDK; Reactive Oxygen Species (ROS) ; SOD
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Isoform
CDK4; CDK6
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Shipping Conditions
Room temperature
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CDK4/6-IN-26
CDK4/6-IN-26 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.