CDK4-IN-1 [CAS 1256963-02-6]
CDK4-IN-1 [CAS 1256963-02-6]
SKU:QM-0084344
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Product Details
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Description
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1].
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CAS Number
[1256963-02-6]
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Molecular Formula
C22H29ClN8
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Molecular Weight
440.97
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Smiles
CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(Cl)NN=C4C(C)C)=N3)C=C2)CC1)C
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Target
CDK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H301-H311-H331
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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CDK4-IN-1 [CAS 1256963-02-6]
CDK4-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.