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CDK6/9-IN-2 [CAS 3068529-24-5]
CDK6/9-IN-2 [CAS 3068529-24-5]
SKU:QM-0012765
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Product Details
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Description
CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) . CDK6/9-IN-2 is selective for CDK2, CDK8, and CDK11. CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ/TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research[1].
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CAS Number
[3068529-24-5]
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Molecular Formula
C25H30ClN7O
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Molecular Weight
480.01
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Smiles
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(NC4=CC=C(C=C4)N5CC[C@@H](C5)O)=N3)Cl
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Target
CDK; Interleukin Related; STAT
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Isoform
CDK6; CDK9; IL-1; IL-6; IL-8; STAT3
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Shipping Conditions
Room temperature
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CDK6/9-IN-2 [CAS 3068529-24-5]
CDK6/9-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.