1
/
of
1
CDK6/PIM1-IN-1 [CAS 2677026-14-9]
CDK6/PIM1-IN-1 [CAS 2677026-14-9]
SKU:QM-0065044
Price on request
Quantity
Request quote or documents
![CDK6/PIM1-IN-1 [CAS 2677026-14-9]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
-
Description
CDK6/PIM1-IN-1 is a potent and balanced dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC50=3.6 nM) . CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].
-
CAS Number
[2677026-14-9]
-
Molecular Formula
C25H28FN9
-
Molecular Weight
473.55
-
Smiles
FC1=CN=C(NC2=NC=C(N3CCNCC3)C=C2)N=C1C4=CC=C5N=CC(N(CC)CC)=NC5=C4
-
Target
Apoptosis; CDK; Pim
-
Isoform
CDK1; CDK12; CDK13; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9; PIM1; PIM2; PIM3
-
Solubility
10 mM in DMSO
-
Shipping Conditions
Room temperature
Related Products
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0015976 Tubulin-IN-62
- QM-0015963 Tubulin polymerization-IN-84 [CAS 2982893-14-9]
- QM-0015797 Tubulin-IN-61
- QM-0015796 Tubulin-IN-60
- QM-0015606 Tubulin-IN-59
- QM-0015240 Tubulin polymerization/P-gp-IN-1
- QM-0015176 Tubulin-IN-58
- QM-0015147 Tubulin-IN-57
Other industry favorites
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0013259 Tubulin-IN-54
- QM-0013216 Tubulin-IN-53
- QM-0161799-01 VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0161801-01 VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0013784 Tubulin/LSD1-IN-1
- QM-0013695 Tubulin polymerization-IN-80
- QM-0151970-01 Tubulin/JAK2-IN-1 [CAS 2933938-46-4]
- QM-0151842-01 Tubulin polymerization-IN-47 [CAS 2834087-62-4]
CDK6/PIM1-IN-1 [CAS 2677026-14-9]
CDK6/PIM1-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.