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CDK7-IN-26 [CAS 3024545-79-4]
CDK7-IN-26 [CAS 3024545-79-4]
SKU:QM-0072790
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Product Details
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Description
CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor (IC50: 7.4 nM) . CDK7-IN-26 potently inhibits the growth of triple-negative breast cancer (TNBC) cell line-derived xenograft (CDX) tumors in vivo and inhibits MDA-MB-453 cells in vitro with an IC50 of 0.15 μM[1].
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CAS Number
[3024545-79-4]
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Molecular Formula
C22H22FN6OPS
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Molecular Weight
468.49
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Smiles
O=P(C)(C1=C(C=CC2=C1NC=C2C3=NC(N[C@H]4C[C@H](F)CNC4)=NC5=C3SC=C5)C#N)C
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Target
CDK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK7-IN-26 [CAS 3024545-79-4]
CDK7-IN-26 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.