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CDK8-IN-12 [CAS 2613307-67-6]
CDK8-IN-12 [CAS 2613307-67-6]
SKU:QM-0149770-01
£313.65 GBP
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Product Details
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Description
CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent[1].
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CAS Number
[2613307-67-6]
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Molecular Formula
C21H20ClN3O2
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Molecular Weight
381.86
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Smiles
O=C1NCCC12CCN(C3=C(C4=CC5=CC=CC=C5O4)C=NC=C3Cl)CC2
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Target
CDK; GSK-3; PKC
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Isoform
CDK8; GSK-3α; GSK-3β; PKCθ
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Purity
99.74
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Solubility
DMSO : 66.67 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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CDK8-IN-12 [CAS 2613307-67-6]
CDK8-IN-12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.