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CDK8-IN-16 [CAS 1860885-61-5]
CDK8-IN-16 [CAS 1860885-61-5]
SKU:QM-0009838-01
£1,368.28 GBP
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Product Details
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Description
CDK8-IN-16 (Compound 51) is an orally active dual inhibitor for CDK8 and CDK19 wih IC50 of 5.1 nM and 5.6 nM. CDK8-IN-16 inhibits the phospho-STAT1SER727 with an IC50 of 17.9 nM in SW620 cell, inhibits WNT signaling pathway with an IC50 of 7.2 nM in 7dF3 cell. CDK8-IN-16 exhibits good pharmacokinetic characteristics in rat models with an oral bioavailability of 57%[1].
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CAS Number
[1860885-61-5]
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Molecular Formula
C23H22N6O2
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Molecular Weight
414.46
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Smiles
O=C(N1CC(C1)OC)C2=NC3=C(C4=CC=C(C5=CN(C)N=C5)C=C4)C=NC(N)=C3C=C2
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Target
CDK; STAT; Wnt
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Isoform
CDK19; CDK8
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Shipping Conditions
Room temperature
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CDK8-IN-16 [CAS 1860885-61-5]
CDK8-IN-16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.