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CDK8-IN-6 [CAS 2415156-27-1]
CDK8-IN-6 [CAS 2415156-27-1]
SKU:QM-0067509
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Product Details
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Description
CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer[1].
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CAS Number
[2415156-27-1]
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Molecular Formula
C26H37ClN2
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Molecular Weight
413.04
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Smiles
C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2
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Target
CDK
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Isoform
CDK8
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK8-IN-6 [CAS 2415156-27-1]
CDK8-IN-6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.