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CDK8-IN-7 [CAS 2415156-30-6]
CDK8-IN-7 [CAS 2415156-30-6]
SKU:QM-0067510
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Product Details
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Description
CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
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CAS Number
[2415156-30-6]
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Molecular Formula
C30H40N2
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Molecular Weight
428.65
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Smiles
C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
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Target
CDK
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Isoform
CDK8
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK8-IN-7 [CAS 2415156-30-6]
CDK8-IN-7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.