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CDK9/10/GSK3β-IN-1 [CAS 2423045-06-9]
CDK9/10/GSK3β-IN-1 [CAS 2423045-06-9]
SKU:QM-0069327
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Product Details
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Description
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 μM) and HsCDK2/CyclinA (IC50=1.725 μM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines[1].
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CAS Number
[2423045-06-9]
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Molecular Formula
C29H24ClN3O4S
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Molecular Weight
546.04
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Smiles
ClC1=CC(SC2=NC3=CC=CC=C3N2C)=CC=C1C(OC4=C5C(O)=CC(O)=C4C(CC6)=CCN6C)=CC5=O
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Target
CDK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK9/10/GSK3β-IN-1 [CAS 2423045-06-9]
CDK9/10/GSK3β-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.