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CDK9-Cyclin T1 PPI-IN-1 [CAS 2995336-58-6]
CDK9-Cyclin T1 PPI-IN-1 [CAS 2995336-58-6]
SKU:QM-0072295
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Product Details
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Description
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective CDK9-Cyclin T1 protein-protein interaction (PPI) inhibitor. CDK9-Cyclin T1 PPI-IN-1 inhibits cell proliferation in TNBC MDA-MB-231 cells (IC50: 0.044 μM), and induces apoptosis. CDK9-Cyclin T1 PPI-IN-1 inhibits CDK9 transcription activity, reduces the phosphorylation of RNA Pol II CTD ser2. CDK9-Cyclin T1 PPI-IN-1 inhibits tumor growth in a TNBC 4T1 mouse model[1].
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CAS Number
[2995336-58-6]
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Molecular Formula
C23H24N4O3
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Molecular Weight
404.46
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Smiles
COC1=CC=C(C=C1)C(NC2=CC(C3=CC(N4CCC(CC4)O)=NC=C3)=CC=N2)=O
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Target
Apoptosis; CDK
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK9-Cyclin T1 PPI-IN-1 [CAS 2995336-58-6]
CDK9-Cyclin T1 PPI-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.