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CDK9 degrader-1
CDK9 degrader-1
SKU:QM-0013916
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Quantity
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Product Details
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Description
CDK9 degrader-1 (Compound AZ-9) is a selective CDK9 degrader (DC50: 0.4073 µM) . CDK9 degrader-1 recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuses with lysosomes to degrade CDK9 and its partner protein Cyclin T1 (DC50: 1.215 µM) . CDK9 degrader-1 induces caspase 3-mediated apoptosis. CDK9 degrader-1 has antitumor activity in a mouse HCT116 xenograft model[1].
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Molecular Formula
C32H34Cl2N6O4
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Molecular Weight
637.56
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Smiles
ClC1=C(C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O)C(Cl)=CC=C1
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Target
CDK
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Isoform
CDK9
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Shipping Conditions
Room temperature
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CDK9 degrader-1
CDK9 degrader-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.