CDK9-IN-37
CDK9-IN-37
SKU:QM-0011562
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Product Details
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Description
CDK9-IN-37 (Compound 24) is a CDK9 inhibitor (EC50: 5.5 nM) with weak inhibition on other CDK isoforms, showing high selectivity. CDK9-IN-37 has significant antiproliferative activity against acute myeloid leukemia MOLM-13 cells (IC50: 0.034 μM) . CDK9-IN-37 inhibits the CDK9 signaling pathway, reduces the phosphorylation level of RNAP II CTD (Ser2), downregulates the anti-apoptotic protein McI-1, induces cell apoptosis, and arrests the cell cycle at the G2/M phase. CDK9-IN-37 can be used in the study of acute myeloid leukemia (AML) [1].
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Molecular Formula
C20H19FN2O4S2
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Molecular Weight
434.5
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Smiles
CCOC1=C(C(C2=CN=C(NC3=CC(C)=CC(S(=O)(C)=O)=C3)S2)=O)C=CC(F)=C1
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Target
CDK
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Isoform
CDK9
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Shipping Conditions
Room temperature
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CDK9-IN-37
CDK9-IN-37 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.