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CDKI-83 [CAS 1189558-88-0]

CDKI-83 [CAS 1189558-88-0]

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SKU:QM-0119151

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  • Description

    CDKI-83 is a potent CDK9 and CDK1 inhibitor with Ki values of 21 nM and 72 nM for CDK9/T1 and CDK1/B, respectively. CDKI-83 demonstrates effective anti-proliferative activity in human tumour cell lines with a GI50apoptosis in A2780 human ovarian cancer cells. CDKI-83 reduces phosphorylation at Ser-2 of RNA polymerase II (RNAPII) by inhibiting cellular CDK9 activity, and down-regulates Mcl-1 and Bcl-2. CDKI-83 has the potential for anti-cancer research[1].

  • CAS Number

    [1189558-88-0]

  • Molecular Formula

    C21H23N7O3S2

  • Molecular Weight

    485.58

  • Smiles

    N#CC1=CN=C(N=C1C2=C(N=C(S2)NC)C)NC3=CC=C(C(S(=O)(N4CCOCC4)=O)=C3)C

  • Target

    Apoptosis; Bcl-2 Family; CDK

  • Isoform

    CDK1; CDK2; CDK4; CDK7; CDK9

  • Shipping Conditions

    Room temperature

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CDKI-83 [CAS 1189558-88-0]

CDKI-83 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.