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P60-L3-VHL

P60-L3-VHL

Size

QM-0111495-01

£545.72 GBP
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Product Details

  • Description

    P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand (HY-162945) ; Pink: target protein ligand (HY-162946) ; Black: linker (HY-162947) ) [1].

  • Molecular Formula

    C135H189N33O27S3

  • Molecular Weight

    2802.35

  • Smiles

    O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)(C)C)NC(COCCOCCNC(CCCCCN2C=C(CCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N7CCC[C@H]7C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CO)=O)=O)=O)=O)=O)N=N2)=O)=O)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10

  • Target

    PROTACs

  • Purity

    99.84

  • Solubility

    H2O : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Blue Ice
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Variant Variant total Quantity Price Variant total
1 mgQM-0111495-01
1 mgQM-0111495-01
£545.72/ea		 £0.00
£545.72/ea £0.00
5 mgQM-0111495-02
5 mgQM-0111495-02
£1,289.30/ea		 £0.00
£1,289.30/ea £0.00
10 mgQM-0111495-03
10 mgQM-0111495-03
£2,032.88/ea		 £0.00
£2,032.88/ea £0.00
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P60-L3-VHL

P60-L3-VHL is a PROTAC (Proteolysis Targeting Chimera)-class Foxp3 degrader supplied by Quantimol as a certified reference standard for laboratory and scientific research.

P60-L3-VHL reduces cell differentiation and Foxp3 expression in activated regulatory T (Treg) cells in vitro and has demonstrated anti-tumor activity in preclinical models.

Compound architecture:

  • E3 ligase ligand (VHL binder): HY-162945
  • Target protein ligand (Foxp3 binder): HY-162946
  • Linker: HY-162947

Key properties:

  • Compound class: PROTAC / Targeted protein degrader
  • Target: Foxp3 (Forkhead box P3)
  • E3 ligase: VHL (Von Hippel-Lindau)
  • Application: Treg biology, immuno-oncology, cancer immunotherapy research
  • Storage: -20°C, protected from light and moisture
  • Solubility: DMSO (recommended)

Supplied by Quantimol as a high-purity reference standard for research use only. Not for human or veterinary use.