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PLK1-IN-10 [CAS 2991469-21-5]
PLK1-IN-10 [CAS 2991469-21-5]
SKU:QM-0130130
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Product Details
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Description
PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death[1].
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CAS Number
[2991469-21-5]
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Molecular Formula
C23H22FN3O4S
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Molecular Weight
455.5
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Smiles
CN(C)CCN(C1=O)C(C2=CC=C(S(NCC3=CC=C(F)C=C3)(=O)=O)C4=CC=CC1=C42)=O
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Target
Polo-like Kinase (PLK)
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Isoform
PLK1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PLK1-IN-10 [CAS 2991469-21-5]
PLK1-IN-10 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.