PLK1-IN-9 [CAS 893772-67-3]
PLK1-IN-9 [CAS 893772-67-3]
SKU:QM-0167994
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Product Details
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Description
PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1].
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CAS Number
[893772-67-3]
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Molecular Formula
C12H7F3N4O2
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Molecular Weight
296.2
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Smiles
CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2
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Target
Polo-like Kinase (PLK)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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PLK1-IN-9 [CAS 893772-67-3]
PLK1-IN-9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.