PROTAC CDK4/6 degrader 1 [CAS 3025082-14-5]
PROTAC CDK4/6 degrader 1 [CAS 3025082-14-5]
SKU:QM-0153613-01
Couldn't load pickup availability
Request quote or documents
![PROTAC CDK4/6 degrader 1 [CAS 3025082-14-5]](http://quantimol.com/cdn/shop/files/quantimol-021.png?v=1773515276&width=1445)
Product Details
-
Description
PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader for CDK4 and CDK6 with DC50 of 10.5 and 2.5 nM. PROTAC CDK4/6 degrader 1 inhibits the proliferation of cell Jurkat (IC50 is 0.18 μM), arrests the cell cycle at G1 phase and induces apoptosis. (Pink: ligand for target protein YY173 ; Black: linker (HY-163788) ; Blue: ligand for E3 ligase (HY-10984) )
-
CAS Number
[3025082-14-5]
-
Molecular Formula
C41H47N11O6
-
Molecular Weight
789.88
-
Smiles
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8
-
Target
Apoptosis; CDK; PROTACs
-
Isoform
CDK4; CDK6
-
Purity
98.88
-
Solubility
DMSO : 100 mg/mL (ultrasonic)
-
Storage Conditions
-20°C (Powder, protect from light)
-
Shipping Conditions
Blue Ice
Related Products
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0015976 Tubulin-IN-62
- QM-0015963 Tubulin polymerization-IN-84 [CAS 2982893-14-9]
- QM-0015797 Tubulin-IN-61
- QM-0015796 Tubulin-IN-60
- QM-0015606 Tubulin-IN-59
- QM-0015240 Tubulin polymerization/P-gp-IN-1
- QM-0015176 Tubulin-IN-58
- QM-0015147 Tubulin-IN-57
Other industry favorites
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0013259 Tubulin-IN-54
- QM-0013216 Tubulin-IN-53
- QM-0161799-01 VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0161801-01 VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0013784 Tubulin/LSD1-IN-1
- QM-0013695 Tubulin polymerization-IN-80
- QM-0151970-01 Tubulin/JAK2-IN-1 [CAS 2933938-46-4]
- QM-0151842-01 Tubulin polymerization-IN-47 [CAS 2834087-62-4]
PROTAC CDK4/6 degrader 1 [CAS 3025082-14-5]
PROTAC CDK4/6 degrader 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.