PROTAC CDK9 degrader-11 [CAS 3039540-19-4]
PROTAC CDK9 degrader-11 [CAS 3039540-19-4]
SKU:QM-0009761
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Product Details
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Description
PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC degrader for CDK9 with DC50 of 1.09 nM. PROTAC CDK9 degrader-11 exhibits cytotoxicity in multi small cell lung cancer cell with IC50 of nanomolar levels. PROTAC CDK9 degrader-11 arrests cell cycle at G0/G1 phase, inhibits the cell invasion in DMS114 and DMS53 cell. PROTAC CDK9 degrader-11 exhibits antitumor efficacy in NCI-H446 xenograft mouse models[1]. (Pink: ligand for target protein CDK9 ligand 3 ; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56 (HY-W247437) )
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CAS Number
[3039540-19-4]
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Molecular Formula
C39H48Cl2N10O5
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Molecular Weight
807.77
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Smiles
O=C(NC1=CNN=C1C(NC2CCN(CC2)C(CN3CCC(CC3)CN4CCN(CC4)C5=CC(NC6C(NC(CC6)=O)=O)=CC=C5)=O)=O)C7=C(C=CC=C7Cl)Cl
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Target
CDK; PROTACs
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Shipping Conditions
Room temperature
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PROTAC CDK9 degrader-11 [CAS 3039540-19-4]
PROTAC CDK9 degrader-11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.