PROTAC tubulin-Degrader-1
PROTAC tubulin-Degrader-1
SKU:QM-0073470
Request quote or documents
Product Details
-
Description
PROTAC tubulin-Degrader-1 is a α/β/β3-tubulin PROTAC degrader. PROTAC tubulin-Degrader-1 exhibits potent anti-proliferative activity against multiple human tumor cell lines. PROTAC tubulin-Degrader-1 induces G2/M phase arrest and apoptosis and inhibits colony formation in A549 and A549/Taxol cells. PROTAC tubulin-Degrader-1demonstrates potent anti-tumor efficacy in A549 and A549/Taxol (Taxol-resistant) xenograft model. PROTAC tubulin-Degrader-1 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: Tubulin ligand , Blue: CRBN Ligand (HY-10984), Black: Linker (HY-N6056) ).
-
Molecular Formula
C35H35N3O10
-
Molecular Weight
657.67
-
Smiles
COC1=C(OC)C(OC)=CC(/C=C\C2=CC=C(OC)C(OC(CCCN3C(CCC(N4C(C(C(N)=CC=C5)=C5C4=O)=O)C3=O)=O)=O)=C2)=C1
-
Target
Apoptosis; Microtubule/Tubulin; PROTACs
-
Isoform
Cereblon
-
Solubility
10 mM in DMSO
-
Shipping Conditions
Room temperature
Related Products
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0015976 Tubulin-IN-62
- QM-0015963 Tubulin polymerization-IN-84 [CAS 2982893-14-9]
- QM-0015797 Tubulin-IN-61
- QM-0015796 Tubulin-IN-60
- QM-0015606 Tubulin-IN-59
- QM-0015240 Tubulin polymerization/P-gp-IN-1
- QM-0015176 Tubulin-IN-58
- QM-0015147 Tubulin-IN-57
Other industry favorites
- QM-0054937 Tubulin polymerization-IN-74 [CAS 54491-43-9]
- QM-0016949-01 Tubulin polymerization-IN-75 [CAS 5325-66-6]
- QM-0013259 Tubulin-IN-54
- QM-0013216 Tubulin-IN-53
- QM-0161799-01 VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0161801-01 VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit
- QM-0013784 Tubulin/LSD1-IN-1
- QM-0013695 Tubulin polymerization-IN-80
- QM-0151970-01 Tubulin/JAK2-IN-1 [CAS 2933938-46-4]
- QM-0151842-01 Tubulin polymerization-IN-47 [CAS 2834087-62-4]
PROTAC tubulin-Degrader-1
PROTAC tubulin-Degrader-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.