Quizartinib [CAS 950769-58-1]

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SKU:QM-0143019-01

£101.50 GBP

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Product Details

Description
Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
CAS Number
[950769-58-1]
Molecular Formula
C29H32N6O4S
Molecular Weight
560.67
Smiles
O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3
Target
Apoptosis; FLT3; Ligands for Target Protein for PROTAC
Purity
99.08
Solubility
DMF : 10 mg/mL (ultrasonic) |DMSO : ≥ 33 mg/mL
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H302, H315, H319, H335
Precautions
H302, H315, H319, H335

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0143019-01	5 mgQM-0143019-01 £101.50/ea	£0.00	Quantity	£101.50/ea	£0.00

10 mgQM-0143019-02	10 mgQM-0143019-02 £131.88/ea	£0.00	Quantity	£131.88/ea	£0.00

50 mgQM-0143019-03	50 mgQM-0143019-03 £248.04/ea	£0.00	Quantity	£248.04/ea	£0.00

100 mgQM-0143019-04	100 mgQM-0143019-04 £381.69/ea	£0.00	Quantity	£381.69/ea	£0.00

200 mgQM-0143019-05	200 mgQM-0143019-05 £629.55/ea	£0.00	Quantity	£629.55/ea	£0.00

500 mgQM-0143019-06	500 mgQM-0143019-06 £1,126.49/ea	£0.00	Quantity	£1,126.49/ea	£0.00

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Quizartinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.