Topoisomerase I/II-IN-1
Topoisomerase I/II-IN-1
SKU:QM-0012786
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Product Details
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Description
Topoisomerase I/II-IN-1 is a dual inhibitor of topoisomerase I/II. Topoisomerase I/II-IN-1 induces G2/M arrest and apoptosis in cancer cells by upregulating p53, p21, and Bax mRNA levels, caspase-3 protein levels, and the Bax/Bcl-2 ratio, while downregulating Bcl-2. Topoisomerase I/II-IN-1 is useful in the study of various cancers, including melanoma, renal cancer, colorectal cancer, and breast cancer[1].
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Molecular Formula
C33H31FN4O7
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Molecular Weight
614.62
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Smiles
O=C(C1CC=C(C(CN2CCN(CC2)C3=C(C=C4C(C(C(O)=O)=CN(C4=C3)C5CC5)=O)F)=C1)O)/C=C/C6=CC=CC([N+]([O-])=O)=C6
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Target
Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; Topoisomerase
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Isoform
Caspase 3; Topo I; Topo II
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Shipping Conditions
Room temperature
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Topoisomerase I/II-IN-1
Topoisomerase I/II-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.