Topoisomerase I-IN-18
Topoisomerase I-IN-18
SKU:QM-0015191
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Product Details
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Description
Topoisomerase I-IN-18, a derivative of Thiosemicarbazide , is a Topoisomerase I inhibitor. Topoisomerase I-IN-18 can disrupt DNA synthesis and transcription. Topoisomerase I-IN-18 inhibits tumor cell proliferation by inducing S-phase cell cycle arrest. Topoisomerase I-IN-18 can enhance mitochondria-mediated apoptosis, suppress cell migration, and increase intracellular Reactive Oxygen Species (ROS) levels. Topoisomerase I-IN-18 can increase p53 protein expression, γH2AX phosphorylation, upregulate Bax expression, downregulate Bcl-2 expression, and activate the caspase cascade. Topoisomerase I-IN-18 can be used for the study of lung cancer[1].
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Molecular Formula
C23H34FN5S
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Molecular Weight
431.61
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Smiles
FC1=CC=C(CN2CC(CCCN3CCC4)C3C4C2CCC/C=N/NC(N)=S)C=C1
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Target
Caspase; DNA/RNA Synthesis; MDM-2/p53; Reactive Oxygen Species (ROS) ; Topoisomerase
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Shipping Conditions
Room temperature
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Topoisomerase I-IN-18
Topoisomerase I-IN-18 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.