Topoisomerase IIα-IN-10
Topoisomerase IIα-IN-10
SKU:QM-0009416
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Product Details
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Description
Topoisomerase IIα-IN-10 (Compound 13r) is an inhibitor of Topoisomerase IIα. It binds to the active site of DNA when complexed with Topoisomerase IIα, and this binding is stabilized through interactions with DNA base pairs and amino acid residues. Topoisomerase IIα-IN-10 can induce Apoptosis by intercalating DNA and inhibiting Topoisomerase IIα, thereby disrupting the mitochondrial membrane potential and inhibiting the growth of HCT116 cell lines, with an IC50 of 4.37 μM against HCT116 cells. Topoisomerase IIα-IN-10 can be used for research in the field of cancer treatment[1].
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Molecular Formula
C32H27N3O3
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Molecular Weight
501.58
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Smiles
O=C1C(/C(C)=N/CC2=CC3=C(C(C4=CC=C(C(C)C)C=C4)=N2)NC5=C3C=CC=C5)=C(O)C6=C(O1)C=CC=C6
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Target
Apoptosis; Mitochondrial Metabolism; Topoisomerase
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Shipping Conditions
Room temperature
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Topoisomerase IIα-IN-10
Topoisomerase IIα-IN-10 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.