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Topoisomerase IIα-IN-4 [CAS 2860554-26-1]
Topoisomerase IIα-IN-4 [CAS 2860554-26-1]
SKU:QM-0069387
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Product Details
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Description
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].
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CAS Number
[2860554-26-1]
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Molecular Formula
C25H21NO2
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Molecular Weight
367.44
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Smiles
O=C(NC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1)CCC4=CC=CC=C4
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Target
Apoptosis; Topoisomerase
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Isoform
Topo II
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Topoisomerase IIα-IN-4 [CAS 2860554-26-1]
Topoisomerase IIα-IN-4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.