Tubulin Polymerization-IN-1 prodrug [CAS 3033099-32-7]
Tubulin Polymerization-IN-1 prodrug [CAS 3033099-32-7]
SKU:QM-0097725
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Product Details
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Description
Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a palladium (Pd) -mediated tubulin polymerization inhibitor prodrug. Developed based on colchicine binding site inhibitors (CBSIs), it reduces toxicity and enhances targeted release properties. Compared to the parent compound, Tubulin Polymerization-IN-1 prodrug exhibited 68.3-fold lower cytotoxicity, which can be restored in situ in the presence of Pd resin. Mechanistic studies showed that its anticancer activity is consistent with CBSIs. In vivo, Tubulin Polymerization-IN-1 prodrug significantly inhibited tumor growth (63.2%) when activated by Pd resin. It holds promise for research in the field of anticancer therapy[1].
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CAS Number
[3033099-32-7]
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Molecular Formula
C22H23FN2O4
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Molecular Weight
398.43
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Smiles
FC(C=C1C(NCC2=CC=C(OC)C(OCC#C)=C2)=O)=CC=C1N3CCOCC3
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Target
Microtubule/Tubulin
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Shipping Conditions
Room temperature
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Tubulin Polymerization-IN-1 prodrug [CAS 3033099-32-7]
Tubulin Polymerization-IN-1 prodrug is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.