Tubulin polymerization-IN-67
Tubulin polymerization-IN-67
SKU:QM-0093993
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Product Details
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Description
Tubulin polymerization-IN-67 (Compound 5h) is an inhibitor for tubulin polymerization on colchicine binding site with an IC50 of 2.92 μM. Tubulin polymerization-IN-67 inhibits the proliferation of cancer cells HT29, A549, U2OS, MG-63 and HeLa with IC50s of 0.12-4.13 μM. Tubulin polymerization-IN-67 arrests the cell cycle at G2/M phase, induces apoptosis in cell U2OS, inhibits the cell migration of A549. Tubulin polymerization-IN-67 reduces the mitochondrial membrane potential (MMP) and increase intracellular ROS, inhibits the angiogenesis in HUVECs. Tubulin polymerization-IN-67 exhibits antitumor efficacy in mice[1]
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Molecular Formula
C24H26N2O5
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Molecular Weight
422.47
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Smiles
CC1(C)OC2=C(C3=NNC(C4=CC(OC)=C(OC)C(OC)=C4)=C3)C=CC(OC)=C2C=C1
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Target
Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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Tubulin polymerization-IN-67
Tubulin polymerization-IN-67 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.