Adezmapimod [CAS 152121-47-6]

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SKU:QM-0081898-01

£65.37 GBP

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Product Details

Description
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator[1][2][3].
CAS Number
[152121-47-6]
Molecular Formula
C21H16FN3OS
Molecular Weight
377.43
Smiles
O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
Target
Autophagy; HSP; Mitophagy; Organoid; p38 MAPK
Isoform
P38 MAPK; p38β
Purity
99.96
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H302, H319
Precautions
H302, H319

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0081898-01	5 mgQM-0081898-01 £65.37/ea	£0.00	Quantity	£65.37/ea	£0.00

10 mgQM-0081898-02	10 mgQM-0081898-02 £94.75/ea	£0.00	Quantity	£94.75/ea	£0.00

10 mM - 1 mLQM-0081898-03	10 mM - 1 mLQM-0081898-03 £101.50/ea	£0.00	Quantity	£101.50/ea	£0.00

50 mgQM-0081898-04	50 mgQM-0081898-04 £136.38/ea	£0.00	Quantity	£136.38/ea	£0.00

100 mgQM-0081898-05	100 mgQM-0081898-05 £231.03/ea	£0.00	Quantity	£231.03/ea	£0.00

200 mgQM-0081898-06	200 mgQM-0081898-06 £301.50/ea	£0.00	Quantity	£301.50/ea	£0.00

500 mgQM-0081898-07	500 mgQM-0081898-07 £551.80/ea	£0.00	Quantity	£551.80/ea	£0.00

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Adezmapimod is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.