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Ruxolitinib [CAS 941678-49-5]

Ruxolitinib [CAS 941678-49-5]

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QM-0077394-01

£108.25 GBP
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Product Details

  • Description

    Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3].

  • CAS Number

    [941678-49-5]

  • Molecular Formula

    C17H18N6

  • Molecular Weight

    306.37

  • Smiles

    N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2

  • Target

    Apoptosis; Autophagy; JAK; Mitophagy

  • Isoform

    JAK1; JAK2; JAK3; Tyk2

  • Purity

    99.99

  • Solubility

    H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302

  • Precautions

    H302
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Variant Variant total Quantity Price Variant total
5 mgQM-0077394-01
5 mgQM-0077394-01
£108.25/ea		 £0.00
£108.25/ea £0.00
10 mM - 1 mLQM-0077394-02
10 mM - 1 mLQM-0077394-02
£117.25/ea		 £0.00
£117.25/ea £0.00
10 mgQM-0077394-03
10 mgQM-0077394-03
£122.88/ea		 £0.00
£122.88/ea £0.00
50 mgQM-0077394-04
50 mgQM-0077394-04
£231.03/ea		 £0.00
£231.03/ea £0.00
100 mgQM-0077394-05
100 mgQM-0077394-05
£290.57/ea		 £0.00
£290.57/ea £0.00
200 mgQM-0077394-06
200 mgQM-0077394-06
£441.23/ea		 £0.00
£441.23/ea £0.00
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Ruxolitinib [CAS 941678-49-5]

Ruxolitinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.