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Sorafenib [CAS 284461-73-0]

Sorafenib [CAS 284461-73-0]

Size

QM-0081737-01

£94.75 GBP
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Product Details

  • Description

    Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

  • CAS Number

    [284461-73-0]

  • Molecular Formula

    C21H16ClF3N4O3

  • Molecular Weight

    464.83

  • Smiles

    O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3

  • Target

    Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; VEGFR

  • Isoform

    B-Raf; C-Raf; PDGFRβ; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

  • Purity

    99.91

  • Solubility

    DMSO : ≥ 45 mg/mL

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
100 mgQM-0081737-01
100 mgQM-0081737-01
£94.75/ea		 £0.00
£94.75/ea £0.00
500 mgQM-0081737-02
500 mgQM-0081737-02
£135.25/ea		 £0.00
£135.25/ea £0.00
1 gQM-0081737-03
1 gQM-0081737-03
£207.95/ea		 £0.00
£207.95/ea £0.00
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Sorafenib [CAS 284461-73-0]

Sorafenib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.