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Sorafenib (tosylate) [CAS 475207-59-1]

Sorafenib (tosylate) [CAS 475207-59-1]

Size

QM-0081748-01

£101.50 GBP
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Product Details

  • Description

    Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator[1].

  • CAS Number

    [475207-59-1]

  • Molecular Formula

    C28H24ClF3N4O6S

  • Molecular Weight

    637.03

  • Smiles

    O=S(C1=CC=C(C=C1)C)(O)=O.O=C(NC2=CC=C(C(C(F)(F)F)=C2)Cl)NC3=CC=C(OC4=CC(C(NC)=O)=NC=C4)C=C3

  • Target

    Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; VEGFR

  • Isoform

    B-Raf; C-Raf; PDGFRβ; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

  • Purity

    99.98

  • Solubility

    DMSO : 100 mg/mL

  • Storage Conditions

    4°C (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
100 mgQM-0081748-01
100 mgQM-0081748-01
£101.50/ea		 £0.00
£101.50/ea £0.00
10 mM - 1 mLQM-0081748-02
10 mM - 1 mLQM-0081748-02
£109.38/ea		 £0.00
£109.38/ea £0.00
500 mgQM-0081748-03
500 mgQM-0081748-03
£125.13/ea		 £0.00
£125.13/ea £0.00
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Sorafenib (tosylate) [CAS 475207-59-1]

Sorafenib (tosylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.