Sunitinib [CAS 557795-19-4]
Sunitinib [CAS 557795-19-4]
SKU:QM-0081894-01
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Product Details
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Description
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].
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CAS Number
[557795-19-4]
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Molecular Formula
C22H27FN4O2
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Molecular Weight
398.47
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Smiles
O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C
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Target
Apoptosis; Autophagy; IRE1; Mitophagy; PDGFR; VEGFR
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Isoform
PDGFRβ; VEGFR2/KDR/Flk-1
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Purity
99.69
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Solubility
DMSO : 20.83 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H360, H372
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Precautions
H360, H372
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Sunitinib [CAS 557795-19-4]
Sunitinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.