Afatinib [CAS 850140-72-6]

Size 5 mg 10 mg 10 mM - 1 mL 50 mg 100 mg 200 mg 500 mg

SKU:QM-0081906-01

£65.37 GBP

Sale Sold out

Shipping calculated at checkout.

Product Details

Description
Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4].
CAS Number
[850140-72-6]
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
Smiles
O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C
Target
Akt; Apoptosis; Autophagy; c-Met/HGFR; EGFR; p38 MAPK
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB3/HER3
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H302, H319, H373, H402
Precautions
H302, H319, H373, H402

Your cart
Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0081906-01	5 mgQM-0081906-01 £65.37/ea	£0.00	Quantity	£65.37/ea	£0.00

10 mgQM-0081906-02	10 mgQM-0081906-02 £94.75/ea	£0.00	Quantity	£94.75/ea	£0.00

10 mM - 1 mLQM-0081906-03	10 mM - 1 mLQM-0081906-03 £101.50/ea	£0.00	Quantity	£101.50/ea	£0.00

50 mgQM-0081906-04	50 mgQM-0081906-04 £231.03/ea	£0.00	Quantity	£231.03/ea	£0.00

100 mgQM-0081906-05	100 mgQM-0081906-05 £275.99/ea	£0.00	Quantity	£275.99/ea	£0.00

200 mgQM-0081906-06	200 mgQM-0081906-06 £336.74/ea	£0.00	Quantity	£336.74/ea	£0.00

500 mgQM-0081906-07	500 mgQM-0081906-07 £527.50/ea	£0.00	Quantity	£527.50/ea	£0.00

Total items

£0.00

Product subtotal

Taxes, discounts and shipping calculated at checkout.

Afatinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.