Birinapant [CAS 1260251-31-7]

Size 5 mg 10 mM - 1 mL 10 mg 50 mg 100 mg

SKU:QM-0153915-01

£122.88 GBP

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Product Details

Description
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.
CAS Number
[1260251-31-7]
Molecular Formula
C42H56F2N8O6
Molecular Weight
806.94
Smiles
FC1=CC2=C(C=C1)C(C[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C3)=C(C(N4)=C(C[C@H]5N(C([C@@H](NC([C@@H](NC)C)=O)CC)=O)C[C@@H](O)C5)C6=C4C=C(F)C=C6)N2
Target
Apoptosis; HIV; IAP
Purity
99.7
Solubility
DMSO : 125 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H302, H315, H319, H335
Precautions
H302, H315, H319, H335

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0153915-01	5 mgQM-0153915-01 £122.88/ea	£0.00	Quantity	£122.88/ea	£0.00

10 mM - 1 mLQM-0153915-02	10 mM - 1 mLQM-0153915-02 £210.38/ea	£0.00	Quantity	£210.38/ea	£0.00

10 mgQM-0153915-03	10 mgQM-0153915-03 £231.03/ea	£0.00	Quantity	£231.03/ea	£0.00

50 mgQM-0153915-04	50 mgQM-0153915-04 £471.61/ea	£0.00	Quantity	£471.61/ea	£0.00

100 mgQM-0153915-05	100 mgQM-0153915-05 £803.30/ea	£0.00	Quantity	£803.30/ea	£0.00

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Birinapant is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.