Cabozantinib [CAS 849217-68-1]

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SKU:QM-0143079-01

£78.82 GBP

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Product Details

Description
Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively) . Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2].
CAS Number
[849217-68-1]
Molecular Formula
C28H24FN3O5
Molecular Weight
501.51
Smiles
O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Target
Apoptosis; c-Kit; c-Met/HGFR; FLT3; TAM Receptor; VEGFR
Isoform
Axl; Met; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Purity
99.96
Solubility
DMSO : 25 mg/mL (ultrasonic)
Storage Conditions
4°C (Powder, protect from light)
Shipping Conditions
Room Temperature
Hazard Statement
H315, H319, H320
Precautions
H315, H319, H320

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0143079-01	5 mgQM-0143079-01 £78.82/ea	£0.00	Quantity	£78.82/ea	£0.00

10 mM - 1 mLQM-0143079-02	10 mM - 1 mLQM-0143079-02 £89.13/ea	£0.00	Quantity	£89.13/ea	£0.00

10 mgQM-0143079-03	10 mgQM-0143079-03 £106.00/ea	£0.00	Quantity	£106.00/ea	£0.00

50 mgQM-0143079-04	50 mgQM-0143079-04 £129.63/ea	£0.00	Quantity	£129.63/ea	£0.00

100 mgQM-0143079-05	100 mgQM-0143079-05 £200.66/ea	£0.00	Quantity	£200.66/ea	£0.00

200 mgQM-0143079-06	200 mgQM-0143079-06 £288.14/ea	£0.00	Quantity	£288.14/ea	£0.00

500 mgQM-0143079-07	500 mgQM-0143079-07 £527.50/ea	£0.00	Quantity	£527.50/ea	£0.00

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Cabozantinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.