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Doramapimod [CAS 285983-48-4]

Doramapimod [CAS 285983-48-4]

Size

QM-0083096-01

£68.47 GBP
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Product Details

  • Description

    Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM) . Doramapimod also inhibits B-Raf with an IC50 of 83 nM[1][2].

  • CAS Number

    [285983-48-4]

  • Molecular Formula

    C31H37N5O3

  • Molecular Weight

    527.66

  • Smiles

    O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3

  • Target

    Autophagy; p38 MAPK; Raf

  • Isoform

    B-Raf; p38 MAPK; p38α; p38β; p38γ; p38δ

  • Purity

    99.98

  • Solubility

    DMSO : 100 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
5 mgQM-0083096-01
5 mgQM-0083096-01
£68.47/ea		 £0.00
£68.47/ea £0.00
10 mM - 1 mLQM-0083096-02
10 mM - 1 mLQM-0083096-02
£76.75/ea		 £0.00
£76.75/ea £0.00
10 mgQM-0083096-03
10 mgQM-0083096-03
£101.50/ea		 £0.00
£101.50/ea £0.00
50 mgQM-0083096-04
50 mgQM-0083096-04
£237.11/ea		 £0.00
£237.11/ea £0.00
100 mgQM-0083096-05
100 mgQM-0083096-05
£306.37/ea		 £0.00
£306.37/ea £0.00
200 mgQM-0083096-06
200 mgQM-0083096-06
£505.63/ea		 £0.00
£505.63/ea £0.00
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Doramapimod [CAS 285983-48-4]

Doramapimod is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.