Everolimus [CAS 159351-69-6]
Everolimus [CAS 159351-69-6]
SKU:QM-0081841-01
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Product Details
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Description
Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].
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CAS Number
[159351-69-6]
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Molecular Formula
C53H83NO14
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Molecular Weight
958.22
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Smiles
O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCO)CC4)OC)C)=O)=O
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Target
Apoptosis; Autophagy; Bacterial; FKBP; mTOR
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Isoform
MTORC1
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Concentration
10mM
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Purity
99.85
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Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H351, H361, H373, H410
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Precautions
H351, H361, H373, H410
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Everolimus [CAS 159351-69-6]
Everolimus is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.