Laduviglusib [CAS 252917-06-9]

Size 5 mg 10 mM - 1 mL 10 mg 50 mg 100 mg

SKU:QM-0081573-01

£108.25 GBP

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Product Details

Description
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3].
CAS Number
[252917-06-9]
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.34
Smiles
N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
Target
Autophagy; GSK-3; Organoid; Wnt; β-catenin
Isoform
GSK-3α; GSK-3β
Purity
99.76
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature
Hazard Statement
H300, H312+H332, H315, H319, H335
Precautions
H300, H312+H332, H315, H319, H335

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Variant	Variant total	Quantity	Price	Variant total
5 mgQM-0081573-01	5 mgQM-0081573-01 £108.25/ea	£0.00	Quantity	£108.25/ea	£0.00

10 mM - 1 mLQM-0081573-02	10 mM - 1 mLQM-0081573-02 £117.25/ea	£0.00	Quantity	£117.25/ea	£0.00

10 mgQM-0081573-03	10 mgQM-0081573-03 £186.08/ea	£0.00	Quantity	£186.08/ea	£0.00

50 mgQM-0081573-04	50 mgQM-0081573-04 £457.02/ea	£0.00	Quantity	£457.02/ea	£0.00

100 mgQM-0081573-05	100 mgQM-0081573-05 £697.60/ea	£0.00	Quantity	£697.60/ea	£0.00

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Laduviglusib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.