LY294002 [CAS 154447-36-6]
LY294002 [CAS 154447-36-6]
SKU:QM-0079943-01
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Product Details
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Description
LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator[3].
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CAS Number
[154447-36-6]
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Molecular Formula
C19H17NO3
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Molecular Weight
307.34
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Smiles
O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4
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Target
Apoptosis; Autophagy; Casein Kinase; DNA-PK; PI3K
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Isoform
PI3Kα; PI3Kβ; PI3Kδ
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Concentration
10mM
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Purity
99.95
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Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319
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Precautions
H302, H315, H319
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LY294002 [CAS 154447-36-6]
LY294002 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.