Midostaurin [CAS 120685-11-2]

Size 1 mg 5 mg 10 mM - 1 mL 10 mg 50 mg 100 mg

SKU:QM-0081864-01

£94.75 GBP

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Product Details

Description
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects[3].
CAS Number
[120685-11-2]
Molecular Formula
C35H30N4O4
Molecular Weight
570.64
Smiles
O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Target
Apoptosis; c-Kit; NO Synthase; PKC; VEGFR
Isoform
ENOS; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCζ; PKCη
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Shipping Conditions
Blue Ice
Hazard Statement
H302, H315, H319, H335
Precautions
H302, H315, H319, H335

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Variant	Variant total	Quantity	Price	Variant total
1 mgQM-0081864-01	1 mgQM-0081864-01 £94.75/ea	£0.00	Quantity	£94.75/ea	£0.00

5 mgQM-0081864-02	5 mgQM-0081864-02 £140.88/ea	£0.00	Quantity	£140.88/ea	£0.00

10 mM - 1 mLQM-0081864-03	10 mM - 1 mLQM-0081864-03 £207.95/ea	£0.00	Quantity	£207.95/ea	£0.00

10 mgQM-0081864-04	10 mgQM-0081864-04 £250.47/ea	£0.00	Quantity	£250.47/ea	£0.00

50 mgQM-0081864-05	50 mgQM-0081864-05 £614.98/ea	£0.00	Quantity	£614.98/ea	£0.00

100 mgQM-0081864-06	100 mgQM-0081864-06 £1,015.92/ea	£0.00	Quantity	£1,015.92/ea	£0.00

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Midostaurin is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.